- Drug Development
- Structural Biology
In 2001, I began working in the field of structural genomics, being Co-PI on the NIGMS-funded Structural Genomics of Pathogenic Protozoa (SGPP) project headed by Wim Hol and the University of Washington. Because of my involvement in the TriTryp genome sequencing projects, my group performed all Target Selection for SGPP. I am currently PI and Director of the Seattle Structural Genomics Center for Infectious Disease (SSGCID), which has been funded under a contract from NIAID since 2007. The mission of SSGCID is to use X-ray crystallography and NMR spectroscopy to solve the structure of proteins targets in emerging and re-emerging infectious disease organisms, primarily to facilitate development of new therapeutics using structure-based drug design, and toward this goal we have solved ~800 protein structures. SSGCID is extremely collaborative; providing clones, purified protein and structures to over 200 investigators around the world. Several of these collaborations have resulted in additional funding from sources such as NIH, BMGF and NATO. One particular success is the Structure Guided Drug Design Consortium (SDDC), which works closely with MMV and the TB Alliance to generate hit-to-lead compounds for malaria and TB.
- Myler PJ, Stacy R, Stewart L, Staker BL, Van Voorhis WC, Varani G, Buchko GW. (2009) The Seattle Structural Genomics Center for Infectious Disease (SSGCID). Infect Disord Drug Targets, 9:493-506. PubMed: 19594426; PubMed Central: PMC2857597.
- Yamada S, Hatta M, Staker BL, et al. (2010) Biological and structural characterization of a host-adapting amino acid in influenza virus. PLoS Pathog, 6:e1001034. PubMed: 20700447; PubMed Central: PMC2916879
- Baugh L, Phan I, Begley DW, et al. (2015) Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95:142-8. PubMed: 25613812; PubMed Central: PMC4361283.
- Staker BL, Buchko GW, Myler PJ (2015) Recent contributions of structure-based drug design to the development of antibacterial compounds. Curr Opin Microbiol, 27:133-8. PubMed: 26458180 PMC4659754 (Available on 10/1/2016)